Named "America's Favorite Drive" for good reason, the Blue Ridge Parkway winds its way through the southern Appalachians and stuns at every bend in the road.  Stretching 465 miles between Shenandoah National Park in the north and Great Smoky Mountains National Park in the south, this mountain region is a natural paradise of forested peaks and sun-dappled valleys painted the prettiest shades of the season.  With a speed limit of 45 mph, you'll be happy this roadway encourages you slow down to enjoy plenty of outdoor adventures and savory pitstops along the way.  Spend a few luxurious days at Primland Resort (shown above), a 5-star mountain estate on your way to Asheville.  When you arrive, a visit to the exquisite Biltmore Estate is a must — as is a night out to celebrate your adventure and enjoy live bluegrass music over a locally brewed pint.